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Sadosky, A., Schaefer, C., Mann, R., Bergstrom, F., Baik, R., Parsons, B., Nalamachu, S., Nieshoff, E., Stacey, B.R., Anschel, A. and Tuchman, M. (2013) Burden of Illness Associated with Painful Diabetic Peripheral Neuropathy among Adults Seeking Treatment in the US: Results from a Retrospective Chart Review and Cross-Sectional Survey. Journal of Diabetes, Metabolic Syndrome and Obesity, 6, 79-92.
http://dx.doi.org/10.2147/DMSO.S37415

has been cited by the following article:

• TITLE: Effectiveness of Metanx Prescription Medical Food on Small Nerve Fibers and Monofilament Sensation in Patients with Diabetic Peripheral Polyneuropathy

  AUTHORS: Victor F. McNamara, Aaron I. Vinik, Lori Barrentine, Edward B. De Vol

  KEYWORDS: Diabetic Neuropathy, Epidermal Nerve Fiber Density, LMF-MC-PP, Monofilament Testing, Small Nerve Fibers

  JOURNAL NAME: Journal of Diabetes Mellitus, Vol.6 No.2, May 6, 2016

  ABSTRACT: Purpose: Diabetic peripheral neuropathy (DPN) is prevalent among the population with type 2 diabetes, and treatment approaches are limited. The combination of L-methylfolate-methylcobalamin-pyridoxal-5-phospate (LMF-MC-PP, Metanx?) is a prescription medical food that has demonstrated significant improvements in sensory perception and quality of life as well as reduced neuropathic pain in patients with DPN. The present study examined the effects of LMF-MC-PP on sensory perception and epidermal nerve fiber density (ENFD) among patients with confirmed DPN. Methods: Patients with type 2 diabetes and diagnosed with diabetic peripheral polyneuropathy, based on loss of vibratory perception, warm-cold discrimination or monofilament sensation, underwent bilateral lower extremity ENFD assessments via skin punch biopsy and were started on LMF-MC-PP. ENFD and monofilament testing were repeated at 6 months. Findings: Of 123 patients evaluated, all had monofilament testing at baseline and 6 months and 122 had assessments at both time points. A significant (p