TITLE:
The Relationship between Central Retinal Artery Resistive Index and Measures of Renal Function in Type 2 Diabetes
AUTHORS:
O. O. Ayoola, D. O. Soyoye, S. D. Dawha, R. T. Ikem, O. H. Onakpoya, T. A. Adedeji, F. A. Arogundade
KEYWORDS:
Ultrasound, Retinal Artery, Renal Function
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.6 No.2,
May
6,
2016
ABSTRACT: Background: Renal and ocular vessels are some of the major vessels affected
in patients with diabetes, and the involvement of these vessels is independent risk
factors for other complications. Hemodynamic flow in arteries may be assessed by
using measures such as resistive index, which is a non-invasive measure of the resistance
in vessels. The association between retinopathy and nephropathy has been conflicting.
This study assessed the relationship between resistive index of the central retinal
artery and indices of nephropathy in type 2 diabetes. Method: This cross-sectional
study examined 74 Nigerian diabetics who were selected consecutively from the out-patient
diabetic clinic of a tertiary hospital in South-West Nigeria. Doppler ultrasound
was used to determine the resistive index of the central retinal artery along with
the right renal artery. The urinary and serum biochemical parameters were also done
to determine the urinary albumin excretion and the glomerular filtration rate. Results:
The mean age of participants was 59.62 ± 9.55 years. The mean central retinal artery
resistive index (CRARI) was 0.77 ± 0.06, with 65 (87.8%) of the participants having
elevated CRARI. There was no statistical difference between patients with normal
CRARI and elevated CRARI in respect of their urinary albumin excretion (p = 0.796).
There was no significant correlation between CRARI and estimated glomerular filtration
rate (r = 0.120; p = 0.309) and right renal artery resistive index (r = 0.068; p
= 0.564). Conclusion: This study demonstrates that central retinal artery resistive
index (CRARI) may not be a predictor of renal function in diabetics.