TITLE:
Synergistic Effect of Watermelon Powder and Lactococcus lactis subsp lactis Supplemented Diet Partially Ameliorates Aβ42-Dependent Lifespan Shorten and Flight Impairment in Transgenic Drosophila
AUTHORS:
Dong Gyun Ko, Young Bum Eun, Jong Uk Na, Sang-Tae Kim
KEYWORDS:
Drosophila melanogaster, Lactococcus lactis, Watermelon, Lifespan, Ommatidia, Aβ42
JOURNAL NAME:
American Journal of Plant Sciences,
Vol.7 No.6,
April
29,
2016
ABSTRACT: Oxidative stress has been strongly related with Alzheimer disease
pathogenesis. We determined the effects of watermelon powder (WMP) and Lactococcus lactis subsp lactis (LAL) supplementation on the
generated Aβ42-induced phenotypes in
a Drosophila melanogaster model of AD. Enhanced Aβ42 expression in D. melanogaster neurons can diminish
lifespan and flight ability. We have observed longevity methods to assay the
effects of WMP and LAL on D. melanogaster survival. Furthermore, flies
expressing Aβ42 in their body fed WMP
and LAL had up to 90 days, or 35% longer median lifespan than those fed a control
diet. In addition, synergistic effect of WMP and LAL improved Aβ42-induced flight impairments in the Drosophila wing tissues.
Our microscope experiments revealed that individuals fed synergistic effect of WMP
and LAL had ameliorated Aβ42
expression as well as increment of flight ability than Aβ42-induced flies. We propose that WMP is typically rich in L-citrulline
and LAL, rich in naturally occurring probiotics and antioxidants, and that it
promotes the survival of neurons in brain and wing muscle tissues with
increased levels of Aβ42 via a
protective cell survival mechanism.