TITLE:
Cu(II) Benzoylpyridine Thiosemicarbazone Complexes: Inhibition of Human Topoisomerase IIα and Activity against Breast Cancer Cells
AUTHORS:
Jennifer D. Conner, Wathsala Medawala, Madison T. Stephens, William H. Morris, Joseph E. Deweese, Patrick L. Kent, Jeffery J. Rice, Xiaohua Jiang, Edward C. Lisic
KEYWORDS:
Topoisomerase IIα, Alpha-(N)-Heterocyclic Thiosemicarbazones, Breast Cancer Cells
JOURNAL NAME:
Open Journal of Inorganic Chemistry,
Vol.6 No.2,
April
29,
2016
ABSTRACT: The focus of this research is on the study of a series of copper (II) benzoylpyridine thiosemicarbazone complexes. Of the six benzoylpyridine thiosemicarbazone ligands used in this study, two are reported for the first time; 2-benzoylpyridine tert-butyl thiosemicarbazone (BZP-tBTSC), and 2-benzoylpyridine benzyl thiosemicarbazone (BZP-BzTSC). Once characterized by NMR, melting point, and MS, these mono-anionic tridentate ligands were then reacted with Cu2+ to form the new square planar metal complexes [Cu(BZP-tBTSC)Cl] and [Cu(BZP-BzTSC)Cl]. All of the copper complexes display marked inhibition of human topoisomerase IIα. The [Cu(BZP-tBTSC)Cl] complex shows marked activity against human breast cancer cell lines.