Article citationsMore>>

Chen, X., Tsiang, M., Yu, F., Hung, M., Jones, G.S., Zeynalzadegan, A., Qi, X., Jin, H., Kim, C.U., Swaminathan, S. and Chen, J.M. (2008) Modeling, analysis and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors. Journal of Molecular Biology, 380, 504-519. doi:10.1016/j.jmb.2008.04.054

has been cited by the following article:

• TITLE: A quantum-chemical model of the inhibition mechanismof viral DNA HIV-1 replication by Iodine complexcompounds

  AUTHORS: Gulnara A. Yuldasheva, Georgii M. Zhidomirov, Aleksandr I. Ilin

  KEYWORDS: HIV; Integrase HIV; Quantum-Chemical Method Ab Initio

  JOURNAL NAME: Natural Science, Vol.3 No.7, July 27, 2011

  ABSTRACT: The interaction of molecular iodine with virus DNA nucleotide is studied by ab initio RHF/3-21G** method. Formation of the nucleoprotein complex of the HIV DNA, molecular iodine and the HIV-1 integrase co-factor is considered to cause the inhibition action of the integrase enzyme. Experimental data on the anti-HIV effect of the molecular iodine complex compounds and the results of calculations suggest that molecular iodine contained in iodine polymer complexes may be considered as a compound inhibiting the catalytic center of the integrase enzyme. Unlike the known integrase inhibitors, molecular iodine also changes the virus DNA structure and produces the N-I bond in the purine bases of adenosine and guanosine nucleotides.