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Borrás-Blasco, J., Navarro-Ruiz, A., Borrás, C. and Casterá E. (2008) Adverse cutaneous reactions associated with the newest antiretroviral drugs in patients with human immunodeficiency virus infection. Journal of Antimicrobial Chemotherapy, 62, 879-888. doi:10.1093/jac/dkn292

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• TITLE: A quantum-chemical model of the inhibition mechanismof viral DNA HIV-1 replication by Iodine complexcompounds

  AUTHORS: Gulnara A. Yuldasheva, Georgii M. Zhidomirov, Aleksandr I. Ilin

  KEYWORDS: HIV; Integrase HIV; Quantum-Chemical Method Ab Initio

  JOURNAL NAME: Natural Science, Vol.3 No.7, July 27, 2011

  ABSTRACT: The interaction of molecular iodine with virus DNA nucleotide is studied by ab initio RHF/3-21G** method. Formation of the nucleoprotein complex of the HIV DNA, molecular iodine and the HIV-1 integrase co-factor is considered to cause the inhibition action of the integrase enzyme. Experimental data on the anti-HIV effect of the molecular iodine complex compounds and the results of calculations suggest that molecular iodine contained in iodine polymer complexes may be considered as a compound inhibiting the catalytic center of the integrase enzyme. Unlike the known integrase inhibitors, molecular iodine also changes the virus DNA structure and produces the N-I bond in the purine bases of adenosine and guanosine nucleotides.