TITLE:
Effects of Size and Surface Charge of Polymeric Nanoparticles on in Vitro and in Vivo Applications
AUTHORS:
Sams M. A. Sadat, Sheikh Tasnim Jahan, Azita Haddadi
KEYWORDS:
Nanoparticle, Size, Surface Charge, In Vitro, In Vivo
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.7 No.2,
April
22,
2016
ABSTRACT: Biodegradable polymeric materials are the most common carriers for use in drug delivery systems.
With this trend, newer drug delivery systems using targeted and controlled release polymeric
nanoparticles (NPs) are being developed to manipulate their navigation in complex in vivo
environment. However, a clear understanding of the interactions between biological systems and
these nanoparticulates is still unexplored. Different studies have been performed to correlate the
physicochemical properties of polymeric NPs with the biological responses. Size and surface
charge are the two fundamental physicochemical properties that provide a key direction to design
an effective NP formulation. In this critical review, our goal is to provide a brief overview on the
influences of size and surface charge of different polymeric NPs in vitro and to highlight the challenges
involved with in vivo trials.