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Van Dole, K.B., Williams, R.E., Brown, R.S., Gaynes, B., Devellis, R. and Funk, M.J. (2010) Longitudinal association of vasomotor symptoms and psychosocial outcomes among postmenopausal women in the United States: A population-based study. Menopause, 17, 917-923. doi:10.1097/gme.0b013e3181d824c8

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• TITLE: Patterns of medication use for the treatment of menopausal symptoms before and after the women’s health initiative; implications for decision-making practices of women and women’s health professionals

  AUTHORS: Chioma Uzoigwe Smith, Srini Rajagopalan, Shiva Sajjan, Shuvayu Sankar Sen, Wenchen Kenneth Wu, Henry Hu

  KEYWORDS: Women’s Health Initiative (WHI); Hormone Replacement Therapy (HRT); Women’s Health; Menopause

  JOURNAL NAME: Health, Vol.3 No.7, July 19, 2011

  ABSTRACT: Background: The Women’s Health Initiative (WHI) published findings in 2002 that changed the perception of the use of hormone replacement therapy (HRT) for the reduction of cardiovascular risks. Menopausal women using HRT for the relief of vasomotor symptoms were advised to use the lowest possible dose of HRT over the shortest possible duration. Objective: This study sought to examine patterns of HRT use for the treatment of menopausal symptoms before and after the WHI among women at least 40 years of age. Methods: A retrospective analysis was performed on a total of 1367 women in the pre-WHI group and 6467 women in the post-WHI group using the U.S. General Electric (GE) Centricity electronic medical record database. Menopause diagnosis was assessed using ICD-9 codes. Clinical characteristics and medication use were assessed for women with at least 3 years of enrollment (1 year baseline, 2 years follow-up). Results: The proportion of women in the post-WHI group that initiated HRT was significantly less than that of women in the pre-WHI group (31.3% vs. 56.9%, respectively; p