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H. Xu, M. Morishima, et al, “Tbx1 has a Dual Role in the Morphogenesis of the Cardiac Outflow Tract,” Develop-ment, Vol. 131, No. 13, 2004, pp. 3217-3227. doi:10.1242/dev.01174

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• TITLE: Anatomy in Patients with 22q11 Deletion and Pulmonary Atresia with Ventricular Septal Defect and Major Aortopulmonary Collaterals

  AUTHORS: Ashish O. Sureka, Lynn F. Peng, Olaf Reinhartz, V. Mohan Reddy, Frank L. Hanley

  KEYWORDS: Tetralogy of Fallot with Pulmonary Atresia, Pulmonary Atresia with Ventricular Septal Defect, 22q11 Deletion

  JOURNAL NAME: Surgical Science, Vol.2 No.5, July 29, 2011

  ABSTRACT: We performed a retrospective analysis of patients with and without 22q11 deletion undergoing surgery for pulmonary atresia with ventricular septal defect and major aortopulmonary collaterals between January 2004 and August 2009 at our institutions. Information was collected on collateral origin, arch sidedness, presence of central pulmonary arteries, and presence of an aberrant subclavian vessel. While patients with 22q11 deletion were more likely to have collateral origin from brachiocephalic vessels, patients without 22q11 deletion were more likely to have collateral origin from the descending aorta. There was no significant difference in arch sidedness or the presence of central pulmonary arteries. Patients with 22q11 deletion were more likely to have an aberrant subclavian artery (15/46 vs 5/54, p