Article citationsMore>>

Sparks, F.T., Lehmann, H., Hernandez, K. and Sutherland, R.J. (2011) Suppression of Neurotoxic Lesion-Induced Seizure Activity: Evidence for a Permanent Role for the Hippocampus in Contextual Memory. PLoS ONE, 6, e27426.

has been cited by the following article:

• TITLE: Contrasting the Amnesic Effects of Temporary Inactivation with Lesions of the Hippocampus on Context Memory

  AUTHORS: Gavin A. Scott, Deborah M. Saucier, Hugo Lehmann

  KEYWORDS: Hippocampus, Retrograde Amnesia, Lesion Size, Temporary Inactivation, Fear Conditioning Memory, Rat

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.6 No.4, April 15, 2016

  ABSTRACT: Lesions and temporary inactivation of the hippocampus (HPC) in rodents occasionally lead to discrepant amnesic effects. We directly compared and contrasted the retrograde amnesic effects that small HPC lesions (~50% damage), large HPC lesions (~80% damage), and combined dorsal and ventral HPC inactivation using the sodium channel blocker tetrodotoxin (TTX) had on contextual fear conditioning. Compared to control rats, large HPC lesions significantly reduced freezing during retention testing, a behaviour consistent with retrograde amnesia. In contrast, neither the small lesions nor the TTX inactivation significantly reduced freezing. The extent of damage was significantly and negatively correlated with retention performance (r(9) = -0.896, p