TITLE:
The Prognostic Significance of the Preoperative Platelet-Lymphocyte Ratio in Japanese Patients with Localized Breast Cancer
AUTHORS:
Hideya Takeuchi, Seiichi Fukuyama, Nobuhide Kubo, Shoji Hiroshige, Hirofumi Kawanaka, Yasuji Yoshikawa, Tokujiro Yano
KEYWORDS:
Platelet-Lymphocyte Ratio, Breast Cancer, Inflammation
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.5 No.2,
April
8,
2016
ABSTRACT: Inflammation has
been shown to be a factor in tumorigenesis. The circulating platelet to lymphocyte
ratio (PLR) is a representative index of systemic inflammation. In this study,
we analyzed the association between preoperative PLR levels and clinicopathological
variables in two hundred sixty-four Japanese patients with localized breast
carcinoma. We also evaluated the prognostic significance of preoperative PLR
levels using the Cox proportional hazard model. Seventy-five patients (28.4%)
had elevated PLR values, whereas 189 (71.6%) had depressed PLR values. The PLR
correlated significantly with venous invasion (P