TITLE:
Hemocompatibility of Albumin Nanoparticles as a Drug Delivery System—An in Vitro Study
AUTHORS:
Mohamed A. Elblbesy
KEYWORDS:
Albumin, Nanoparticles, Hemocompatibility
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.7 No.2,
April
8,
2016
ABSTRACT: As a major plasma protein, albumin has a distinct advantage compared with other materials for
nanoparticle preparation. It is cheap and easily available. The present work aimed to prepare bovine
albumin nanoparticles (BAN) with a simple coacervation method and to test their hemocompatibility.
The albumin nanoparticles obtained by this method had a range of sizes from 250 - 350
nm at pH = 7.4. In vitro hemocompatibility tests of the prepared (BAN) were conducted after the
incubation of BAN with normal blood for 2 h at 37°C. Hemocompatibility tests showed that the reduction
in the hemolysis percentage of erythrocytes was due to exposure to BAN. The other blood
parameters such as hemoglobin (HG), mean corpuscle hemoglobin (MCH), and mean corpuscle
hemoglobin concentration (MCHC) were in the normal range. The prothrombin time (PT) and
erythrocyte sedimentation rate (ESR) decreased as the concentration of BAN increased. The results
obtained in this study demonstrated that BAN could be used safely and without abnormal effect
when interacted with blood through many biomedical applications.