TITLE:
Intramuscular Diffusion Status of Risperidone and Aripiprazole Long Acting Injectable (LAI) by Ultrasonography
AUTHORS:
Yuko Yasuhara, Tetsuya Tanioka, Kensaku Takase, Kazushi Motoki, Chie Watari, Koichi Makiguchi, Asumi Atsuta, Rozzano C. Locsin
KEYWORDS:
Diffusion Status, Risperidone, Aripiprazole, Long Acting Injectable (LAI), Ultrasonography
JOURNAL NAME:
Open Journal of Psychiatry,
Vol.6 No.2,
March
31,
2016
ABSTRACT: The aim of this study was
to consider the characteristics of intramuscular diffusion status of
risperidone and aripiprazole long acting injectable (LAI) by ultrasonography.
Subjects were 40 adult subjects diagnosed with schizophrenia and treated with
LAI [32 patients were risperidone LAI (RLAI) and 8 patients were aripiprazole
LAI (ALAI)]. However, in this paper, only three cases (one RLAI case and 2 ALAI
cases) were selected to illustrate the diffusion effects of both LAI.
Dorsogluteal intramuscular (IM) injection sites were measured at prone position
using the “double cross” method. Before LAI injection, the distance from the
epidermis to the under-fascia (DEUF), and distance from the epidermis to the
iliac bone (DEI) at the IM injection site were assessed by using
ultrasonography: 1) the injection needle was inserted to the gluteus medius,
and 2) observed the diffusion status within the muscle injected RLAI and ALAI
were confirmed using the B-mode ultrasonography. Both RLAI and ALAI were
depicted as high echogenicity with acoustic shadowing. It was considered that
the diffusion states of LAIs by ultrasonography were important time course
evaluations providing objective evidence.