TITLE:
Synthesis of Calcium Phosphate Controllable Coating Thickness on Oil-in-Water Nanoemulsion with Performance of Oxygen Release as Oxygen Carrier
AUTHORS:
Kyu-Bum Han, Curtis Takagi, Chun-Jen Wu, Hiroshi Mizukami, Agnes Ostafin
KEYWORDS:
Perfluorocarbon, Calcium Phosphate, Nanoemulsion, Oxygen Carrier, Surface Coating
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.7 No.2,
March
31,
2016
ABSTRACT: Perfluorocarbon emulsion has been studied as an oxygen carrier, due to its high oxygen content.
In clinical trials, it has shown stability in delivering oxygen to the target region. The purpose of the
present study was to increase the stability of the emulsion by coating its surface with calcium
phosphate. A layer-by-layer method was employed to coat the flexible emulsion surface. Considering
the ionic affinity of calcium and phosphate to the lecithin emulsion surface, the first layer of
coating was calcium and the second layer was comprised of phosphate ion. The coated emulsion
demonstrated various oxygen release times depending on the thickness of the layers: from 0.04
sec. for a thickness of 8 nm to 0.17 sec. for a thickness 38 nm. Overall, the stability of the calcium
phosphate coated emulsion was increased, while its original function as an oxygen carrier was
maintained.