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Bertoni, M., Olivieri, F., Manghetti, M., Boccolini, E., Bellomini, M.G., Blandizzi, C., Bonino, F. and Del Tacca, M. (2002) Effects of a Bicarbonate-Alkaline Mineral Water on Gastric Functions and Functional Dyspepsia: A Preclinical and Clinical Study. Pharmacological Research, 46, 525-531.
http://dx.doi.org/10.1016/S1043661802002323
has been cited by the following article:
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TITLE:
Pilot Trial on the Efficacy and Safety of a Natural Mineral Water Rich in Hydrogen Carbonate on Functional Dyspepsia and Heartburn
AUTHORS:
Ute Pohl, Annegret Auinger, Gordana Bothe, Ralf Uebelhack
KEYWORDS:
Heartburn, Dyspepsia, Natural Mineral Water, “Heilwasser”, Pilot Study, Hydrogen Carbonate
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.6 No.3,
March
30,
2016
ABSTRACT: Background: Dyspepsia and heartburn are among the most frequent complaints of the upper gastrointestinal tract impacting quality of life. The present study aimed to investigate the impact of drinking a natural mineral water (medicinal product category “Heilwasser” in Germany) high in hydrogen carbonate (Staatl. Fachingen STILL) on functional dyspeptic complaints and heartburn. Methods: 56 men and women with self-reported heartburn were enrolled to this one-arm pilot study. They had to drink 1.5 L of a hydrogen carbonate rich mineral water each day over a course of six weeks. Participants reported the number and duration of heartburn episodes in a daily dairy. The Reflux Disease Questionnaire (RDQ), Quality of Life in Reflux and Dyspepsia questionnaire (QOLRAD) and the Gastrointestinal Quality of Life Index (GILQI) were used to assess the therapeutic course of the treatment and the Short Form Health Survey (SF-12) to assess general quality of life. Mean ± standard deviation were calculated and pre- and post-treatment changes were compared using the Wilcoxon test. Results: The consumption of a hydrogen carbonate rich mineral water decreased the number of heartburn episodes per week significantly by 4.8 ± 8.2 at the end of the study (p