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Bastian, J.A., Chrigadze, N., Denny, M.L., Gifford-Moore, D.S., Sall, D.J., Smith, G.F. and Wikel, J.H. (1999) Diamino Benzo[b]thiophene Derivatives as a Novel Class of Active Site Directed Thrombin Inhibitors: 3. Enhancing Activity by Imposing Conformational Restriction in the C-4" Side Chain. Bioorganic & Medicinal Chemistry Letters, 9, 363-368.
http://dx.doi.org/10.1016/S0960-894X(98)00746-X

has been cited by the following article:

• TITLE: New Approaches for the Use of Acetoacetanilide in the Synthesis of Thiophenes and Their Fused Derivatives with Anti-Tumor Activity

  AUTHORS: Rafat M. Mohareb, Sherif M. Sherif, Wagnat W. Wardakhan, Amr S. Abouzied

  KEYWORDS: Acetoaceanilide, Thiophene, Anti-Tumor, Docking

  JOURNAL NAME: Open Access Library Journal, Vol.1 No.8, November 26, 2014

  ABSTRACT: Acetoacetanilide derivatives 1a-c reacted with either malnonitrile or ethyl cyanoacetate and elemental sulfur to give the thiophene derivatives 3a-f. The reactivity of 3a towards some chemical reagents to give thiophene, theino[2,3-b]pyridine, thieno[2,3-c]pyrimidine and coumarin derivatives was studied. The anti-tumor evaluation of the newly synthesized compounds against the three human tumor cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that compounds 8a, 8b and 14 exhibit higher inhibitory effects towards the three tumor cell lines than the positive control doxorubicin.