TITLE:
A Clinical Study on the Treatment of Peripheral Nerve Injury Growth Factor of Mecobalamin Combined with Nerve
AUTHORS:
Chengkua Huang, Guosheng Su, Wen Wei, Wenzhong Lu, Yinwen Mai, Shuliang Hua, Yong Zhao, Jili Lu
KEYWORDS:
Mecobalamin, Nerve Growth Factor, Peripheral Nerve Injury
JOURNAL NAME:
World Journal of Neuroscience,
Vol.6 No.2,
March
23,
2016
ABSTRACT: Objective: This research
aims to explore the clinical curative effect for the treatment peripheral nerve
injury growth factor of Mecobalamin combined with nerve. Methods: 150 cases of
patients with peripheral nerve injury treated in the hospital in July were
selected from 2011 to 2013. Those patients were randomly divided into three
groups according to the types of injured nerve and the undergoing treatment
order. 50 cases are for each group. Patients in group A were injected with 0.5
mg Mecobalamin by intravenous injection. It lasted for once a day, for 10 days.
Later, 0.5 mg Mecobalamin was changed to be taken orally, three times a day, a
course of treatment. And a course is 3 to 6 weeks. 50 patients in group B were
injected with nerve growth factor for 30 micrograms by intramuscular injection,
once a day, a course of treatment. And a course is 3 to 6 weeks. While in group
C, 50 patients were treated with Mecobalamin (0.5 mg, intravenous injection,
once a day) combined with nerve growth factor (30 mg, intramuscular injection,
once a day). A course lasted 3 to 6 weeks. The purpose is to observe the
therapeutic effect of two different drugs on patients with peripheral nerve
injury. Results: The curative effect of Mecobalamin combined with nerve growth
factors for the treatment of peripheral nerve injury in group C is more
significant than the single drug treatment in group A and group B. Peripheral
nerve injury after sensorimotor function rating evaluation of curative effect
made by The British Medical Research Institute of Neurotrauma Society was
applied in this research. The comparison of the results of 3 groups after
treatment is showed as follows. As to the sensory recovery above level II, the
curative effect in C group is generally better than in group A and group B, the
approximate chi square test H = 13.6573, P = 0.0011. About motion recovery
situation, there is a statistical significance in group A and group C which
recovered V level X2=
3.8431, P = 0.0499, while there is no obvious difference in group B (P >
0.05). Conclusion: Some certain curative effect is presented of Mecobalamin
combined with nerve growth factor in the treatment of peripheral nerve injury,
which has an important clinical significance. Therefore, it is worth taking
into application.