TITLE:
The Effect of Micro-Pulsatile Electrical and Ultrasound Stimulation on Cellular Biosynthetic Activities Such as Cellular Proliferation, Endogenous Nitrogen Oxide and Collagen Synthesis
AUTHORS:
Doris-Antoinette Mbeh, Insaf Hadjab, Mihaela-Elena Ungur, L’Hocine Yahia
KEYWORDS:
Collagen, Fibroblasts, NO, Aesthetic Technologies, Ultrasounds, Electric Current
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.6 No.1,
March
22,
2016
ABSTRACT: The skin barrier poses an ongoing challenge for the
cosmetics industry. Its penetration, by non-invasive means, can readily be
achieved with currents and ultrasound or radiofrequency devices through
electroporation, sonophoresis, iontophoresis or cavitation. When several types of energy are applied
simultaneously, we expect the effects to be magnified and all the more
effective. Although the mechanism of action of each technology
on the skin is not entirely controlled, and is even less so when multiple
technologies are applied concurrently, some studies demonstrate that nitric oxide (NO) plays a pivotal role in
skin wound-healing and regeneration. With regard to wound healing, one of the
key functions of NO appears to be its permissive effect on keratinocyte and
fibroblast proliferation, which helps promote wound re-epithelialization. The
objective of the actual research is to gain an in-depth understanding of the
mechanisms generated by NO through the
application of a specific combination of technologies.