TITLE:
Proteomics and Its Applications in Diagnosis of Auto Immune Diseases
AUTHORS:
Gebrehiwot Gebretsadik, M. K. C. Menon
KEYWORDS:
Proteomics, Autoimmune Diseases, Biomarkers, Genomics
JOURNAL NAME:
Open Journal of Immunology,
Vol.6 No.1,
March
18,
2016
ABSTRACT: Although the proteomics and its applications in detecting autoimmune diseases are a prominently
discussed issue, this review will focus particularly some prominent aspects regarding clinical utility
of these techniques in prognosis, diagnosis, and treatment of these diseases. The impact of
immunofluorescent techniques, enzyme immunoassays and use of proteomics biomarkers in the
characterization of the auto immune diseases is briefly discussed. The necessity of adopting existing
technologies of protein chemistry, predisposition testing, targeted monitoring and prevention
of diseases through nutrition coupled with lifestyle changes will be focused as modern diagnostic
tools in realizing the changeover from isolated medicine to personalized medicine. Use of biological
fluids, in order to identify low abundance proteins as biomarkers in detecting autoimmune
diseases is attempted in the study of serum/plasma proteomics.