TITLE:
2D Numerical Simulation of Liver Cell Proliferation with Angiogenesis for Hepatic Lobule Formation
AUTHORS:
Katsuya Nagayama, Hiroto Tanaka, Yuki Oshiumi, Nana Shirakigawa, Hiroyuki Ijima
KEYWORDS:
Particle Simulation, Liver Proliferation, Angiogenesis
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.4 No.3,
March
17,
2016
ABSTRACT: The liver has the ability to reform and regenerate
in our body. However, the mechanisms of reformation or regeneration of the
liver have not been elucidated. In this study, we propose an analysis model
using a Particle Model to elucidate the mechanism of liver formation. The
object of analysis is a hepatic lobule, which is the basic component of the
liver. First, a 2-dimensional cell proliferation around one blood vessel was
modeled. Second, angiogenesis was added and considered. And finally, the model
was applied to the hepatic lobule and the 2D formation of the hepatic lobule
was revealed. We used experimentally derived parameters such as diffusivity,
oxygen concentration, and oxygen consumption of a cell. The model will be
expected to facilitate in developing tissue-engineered liver using regenerative
medicine technology.