TITLE:
Research Progress on Aging Mechanisms
AUTHORS:
Qiang Wang, Fengjuan Zhou, Wenmei Xie, Xiaorong Zhao, Xuan Liu
KEYWORDS:
Aging, Free Radical, Lipoprotein, Apoptosis, Mitochondrial DNA, Genes, Immune System
JOURNAL NAME:
Advances in Aging Research,
Vol.5 No.2,
March
17,
2016
ABSTRACT: Aging refers to a gradual process of functional and organic recession with the age increased after the organism maturing. Many researchers have tried to elucidate aging mechanism which includes the free radical theory: free radicals can become lipofuscin and cause the mutations of mitochondrial DNA (mtDNA), and the damage of the nuclear DNA. From the view of heredity, aging is the results of the activation and inhibition of a series of genes as well as the products of their interaction. From the changes of immune function theory, it points out that aging is attributed to the decline of immune responses and the increase of autoimmune reactions.