TITLE:
Investigation of Pseudomonas aeruginosa Resistance Pattern against Antibiotics in Clinical Samples from Iranian Educational Hospital
AUTHORS:
Zakieh Rostamzadeh, Mahshid Mohammadian, Alireza Rostamzade
KEYWORDS:
Pseudomonas aeruginosa, Resistance, Antibiotics
JOURNAL NAME:
Advances in Microbiology,
Vol.6 No.3,
March
17,
2016
ABSTRACT: Pseudomonas aeruginosa (P. aeroginosa)
is one of the opportunistic pathogens, which is the main cause of prevalent
hospital infections worldwide. The aim of this study was to determine the prevalence
of antibiotic resistance pattern against P.
aeroginosa from clinical samples in our population. This study was
performed during March 2009 to September 2011. During this period 233 clinical
isolated samples from hospital patients were examined. In these studies,
different strains of P. aeroginosa were isolated from samples, then microbiologically tested. Bacterial
susceptibility was performed by the disc-diffusion tests with Kirby Baur disc
diffusion tests in Muller-Hinto environment. Our results showed maximum
antibiotic resistance (99.5%) of P. aeruginosa against Trimetoprime Solfametoxasole and Ciprofloxacin (55.33%), Amikacin (61%),
Imipenem (33%), which were identified as the most effective antibiotics in this
study. In conclusion, indeed most Pseudomonas
aeruginosa strains infections are treated as soon as possible due to their
severe resistance against antibiotics. So, we have to apply an accurate
antibiotic treatment discipline, according to the finding, based on
antibiogram, in order to prevent its spread and also, monitoring and optimization
of antimicrobial use should be considered carefully.