TITLE:
Formulation and Evaluation of Mucoadhesive Microspheres of Pioglitazone Hydrochloride Prepared by Ionotropic External Gelation Technique
AUTHORS:
Nagarajan Sriram, Prakash Katakam
KEYWORDS:
Diabetes Mellitus, Mucoadhesive Microspheres, Mucoadhesive Polymers, Mucoadhesion, Sustained Release, Ionotropic External Gelation Technique
JOURNAL NAME:
Journal of Encapsulation and Adsorption Sciences,
Vol.6 No.1,
March
15,
2016
ABSTRACT: Microspheres containing Pioglitazone hydrochloride were prepared by the
ionotropic external gelation method, using sodium alginate with four
mucoadhesive polymers namely sodium carboxy methyl cellulose, hydroxy propyl methyl
cellulose, carbopol 934 P and cellulose acetate phthalate as coat materials.
Ionotropic gelation is a method to prepare microspheres using combination of Ca2+ as cationic components and alginate as anion. The practical yield of prepared microspheres
using the ionotropic gelation technique was between 172 mg and 604 mg. The
result of the Chi-squared test carried out between the actual (practical) and
expected (theoretical) yields showed no significant difference (P ex-vivo wash-off test shows the best mucoadhesive
property. The in vitro drug release
studies do up to 18 h. As observed from
the various plots, most of the formulations followed the Korsmeyer-Peppas model.