TITLE:
Synthesis of α-Naphthol and 2,4,7-Trimethyl-Quinolin-5-ol by Using Manganese (III) Acetate and Analysis of Its Antimicrobial Properties
AUTHORS:
Gülderen Uysal Akkuş
KEYWORDS:
Manganese (III) Acetate, Biological Activity, Radical Reaction, Aromatic, Ketone
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.6 No.1,
March
15,
2016
ABSTRACT: This study involves the aromatization reactions of some ketone derivatives through Manganese (III) acetate. The ketone derivatives used in the study are α-tetralone (1a), 2,4,7-trimethyl-7,8-dihydro quinolinone (1b). At the end of the aromatization reactions of these ketone derivatives the synthesized structures of α-naphthol (2a), 2,4,7-trimethylquinoline-5-ol (2b) were identified by spectroscopic methods such as IR, 1H-NMR, 13C-NMR, FAB-MS respectively. Micro-organism types such as Escherichia coli, ATCC 25922, Klepsiella pneumoniae, Staphylococcus aureus NRRL B767, Salmonella typhimurium NRRLB 4420, Bacillus subtilis NRS 744, Bacillus cereus ATCC 11778, Micrococcus luteus ATCC-9341, Listeria monoaytopenus ATCC-7644 bacteria and yeast fungus Candida albicans were used to study the anti-microbial properties of the synthesized 2b compound. The obtained results have determined that compound number 2b has a good antibacterial impact on Bacillus subtilis (NRS-744).