TITLE:
Prevalence of Rifampicin Resistance and Associated Risk Factors among Suspected Multidrug Resistant Tuberculosis Cases in TB Centers Mogadishu-Somalia: Descriptive Study
AUTHORS:
Ahmed Y. Guled, Ayub Hassan Elmi, Bashir Mohamud Abdi, Abdihamid Mohamed Ali Rage, Fartun Mohamed Ali, Abdullahi Hassan Abdinur, Abdullahi Abdulle Ali, Anab Adam Ahmed, Khadra Abdullahi Ibrahim, Salah Osman Mohamed, Fos Ali Mire, Omar Abdi Adem, Ali Dirie Osman
KEYWORDS:
Prevalence, Risk Factors, Tuberculosis, Mogadishu
JOURNAL NAME:
Open Journal of Respiratory Diseases,
Vol.6 No.2,
March
11,
2016
ABSTRACT: Introduction and Background: Multidrug-resistant tuberculosis (MDR-TB) has emerged as a significant
global health concern. Patients who had failed previous TB treatment, relapsed after
treatment, contacted known MDRTB patients or defaulted during previous treatment, and HIV patients
are considered to be suspected and at high risk for developing drug resistant TB specially
MDR-TB. However, there is little data available on the prevalence and trends of MDR tuberculosis
in national level but luck of it in Mogadishu is our main concern. Methodology: This was a crosssectional,
descriptive study involving all suspected MDR TB patients attended at the Mogadishu
three Tb centers. Results: A total of 138 cases of suspected MDRTB patients were included in the
study. Of these, 70 patients (51%) had rifampicin resistant-TB. Of the 138 study participants, 94
(68.62%) were between 21 - 40 years old that indicates the dominance of productive age group
(21 - 40 years). Previous Tuberculosis treatment has been noted to be a major risk factor for development
of multidrug resistance tuberculosis. MDR-TB prevalence is significantly higher in male
than female patients. Conclusion and Interpretation: The prevalence of Rifampicin resistance
among these high risk groups was significant. The high association of previous TB treatment to MDR-TB might be explained due to inappropriate anti-tubercular regimens, sub-optimal drugs,
inadequate or irregular drug supply, unsatisfactory patient or clinician compliance, lack of supervision
of treatment and absence of infection control measures in healthcare facilities. As the prevalence
of MDRTB is high and yet the cases remain un-isolated in the community we recommend
the MOH/NTP and funding agencies to facilitate establishment of MDRTB management centers
earlier in Mogadishu in order to treat the MDRTB case otherwise it might Amplify of the incidence
of this Emerging Disease.