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Ozols, Ya.Ya., Pyrko, A.N., Lakhvich, F.A., Vigante, B.A., Dubure, R.R., Dubur, G.Ya. and Akhrem, A.A. (1990) Synthesis of Decahydrophenanthridine-1,7-dione and Hexahydroisoquinol-8-one Derivatives in the Deaction of 2-acetyl-2-cyclohexene-1-ones with Conjugated Enaminocarbonyl Compounds. Chemistry of Heterocyclic Compounds, 26, 58-62.

has been cited by the following article:

• TITLE: Synthesis of Tri- and Tetracycle Compounds via Reaction of 1,3-Decalinediones and 4-Hydroxycoumarines with 2-Acetyl-2-Cyclohexenes and Biological Testing

  AUTHORS: Anatoliyi N. Pyrko, Gennadiyi S. Lyubin, Stanislove L. Bondarev

  KEYWORDS: Synthesis, Decalindion and Coumarine Derivatives, Anticoagulative Activity

  JOURNAL NAME: Open Access Library Journal, Vol.1 No.4, July 10, 2014

  ABSTRACT: 2-Acetyl-5, 5-dimethyl-2-cyclohexen-l-one reacts with decalin-1,3-dions (9a, b) and 4-hydroxy-coumarins (13a, b) following the pattern of a Michael addition with the formation of tricyclic compounds (10a, b and 14a, b). In the case of unsubstituted 2-acetyl-2-cyclohexen-l-one reaction with 4-hydroxycoumarine follows pattern of a DieIs-Alder heterodiene condensation to form tetracycle (15). Dehydration of both types of adduct gives tetracyclic compounds (11a, b and 16a, b, c). Coumarine derivatives (14a, b, 15, 16c) were tested for anticoagulative activity.