Article citationsMore>>

Akhrem, A.A., Lakhvich, F.A. and Pyrko, A.N. (1977) Synthesis of 2-Acetyl-5,5-dimethyl-2-cyclohexen-1-ol and 5,5-dimethyl-2-(α-hydroxyethyl)-2-cyclohexen-1-on. Journal of Organic Chemistry (Russian), 13, 2074-2078.

has been cited by the following article:

• TITLE: Synthesis of Tri- and Tetracycle Compounds via Reaction of 1,3-Decalinediones and 4-Hydroxycoumarines with 2-Acetyl-2-Cyclohexenes and Biological Testing

  AUTHORS: Anatoliyi N. Pyrko, Gennadiyi S. Lyubin, Stanislove L. Bondarev

  KEYWORDS: Synthesis, Decalindion and Coumarine Derivatives, Anticoagulative Activity

  JOURNAL NAME: Open Access Library Journal, Vol.1 No.4, July 10, 2014

  ABSTRACT: 2-Acetyl-5, 5-dimethyl-2-cyclohexen-l-one reacts with decalin-1,3-dions (9a, b) and 4-hydroxy-coumarins (13a, b) following the pattern of a Michael addition with the formation of tricyclic compounds (10a, b and 14a, b). In the case of unsubstituted 2-acetyl-2-cyclohexen-l-one reaction with 4-hydroxycoumarine follows pattern of a DieIs-Alder heterodiene condensation to form tetracycle (15). Dehydration of both types of adduct gives tetracyclic compounds (11a, b and 16a, b, c). Coumarine derivatives (14a, b, 15, 16c) were tested for anticoagulative activity.