TITLE:
The Effect of Insulin Resistance on In-Vitro Fertilization-Embryo Transfer in Women without Polycystic Ovary Syndrome
AUTHORS:
Keiko Mekaru, Sugiko Oishi, Kozue Akamine, Tadatsugu Kinjo, Chiaki Heshiki, Hitoshi Masamoto, Yoichi Aoki
KEYWORDS:
Insulin Resistance, Polycystic Ovary Syndrome, In-Vitro Fertilization-Embryo Transfer, Gestational Diabetes Mellitus
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.6 No.3,
March
1,
2016
ABSTRACT: Purpose: Insulin resistance (IR) plays an important role in the
pathogenesis of polycystic ovary syndrome (PCOS); therefore,
insulin-sensitizing agents are widely used to improve IR in women with PCOS.
However, whether IR in patients without PCOS should be treated remains
uncertain. This study aims to clarify whether IR in patients without PCOS
affects the outcomes of in-vitro fertilization-embryo
transfer (IVF-ET) and pregnancy. Methods: Between January 2011 and December
2013, we retrospectively reviewed the medical records of 116 non-PCOS patients
who underwent the first IVF–ET cycle. IR was calculated using the homeostasis
model assessment (HOMA) index [HOMA-IR = (insulin × glucose)/405]. A HOMA index
of >2.5 was used to indicate IR. Based on the HOMA index calculation, 28
patients were IR(+) and 88 patients had normal insulin sensitivity. We
retrospectively compared the response with controlled ovarian hyperstimulation,
retrieved oocytes number, fertilization rates, pregnancy rate, live birth
rates, and gestational diabetes mellitus (GDM) incidence. Results: There were
no significant differences in human menopausal gonadotropin administration,
peak estradiol, retrieved oocyte number, fertilized embryo number, good quality embryo number, implantation
rate, clinical pregnancy rate, miscarriage rate, delivery rate, or
ovarian hyperstimulation syndrome and GDM incidences between the groups.
Conclusion: IR in non-PCOS patients has no effect on IVF-ET outcomes or perinatal
prognosis.