TITLE:
Curvularin and Dehydrocurvularin as Phytotoxic Constituents from Curvularia intermedia Infecting Pandanus amaryllifolius
AUTHORS:
Kumudini M. Meepagala, Robert D. Johnson, Stephen O. Duke
KEYWORDS:
Curvularia intermedia, Pandanus amaryllifolius, Phytotoxins, Curvularin, Dehydrocurvularin
JOURNAL NAME:
Journal of Agricultural Chemistry and Environment,
Vol.5 No.1,
February
29,
2016
ABSTRACT: Microbes are good sources of biologically active compounds that can be used as pharmaceuticals
and agrochemicals. As part of our continuous efforts in search for biopesticides from natural
sources, a fungus is isolated from leaves of Pandanus amaryllifolius that shows severe necrosis.
This fungus is cultured in potato dextrose agar and identified as Curvularia intermedia. The ethyl
acetate extract of the liquid culture medium is phytotoxic. Identification and bioassay of αβ-dehydrocurvularin
(1) and curvularin (2) from this fungus are described. Monoacetyldehydrocurvularin
(3), and diacetyldehydrocurvularin (4) are synthesized from 1. Phytoxicity rankings in a
variety of bioassays are 1 > 2 > 4 > 3.