TITLE:
NEM® Brand Eggshell Membrane Effective in the Treatment of Pain and Stiffness Associated with Osteoarthritis of the Knee in an Italian Study Population
AUTHORS:
Emy Brunello, Antonio Masini
KEYWORDS:
Knee, Osteoarthritis, Supplement, Egg Shell Membrane, Glycosaminoglycans
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.7 No.2,
February
29,
2016
ABSTRACT: A single-center, open-label clinical study was conducted to evaluate the efficacy and safety of NEM® as a natural treatment for pain and stiffness associated with osteoarthritis of the knee in an Italian population. NEM® brand eggshell membrane is a unique dietary supplement that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy joints and connective tissues. Twenty-five subjects received oral NEM®, 500 mg once daily for four weeks. The primary outcome measure was to evaluate the mean effectiveness of NEM® in relieving general pain associated with moderate osteoarthritis of the knee at 10 and 30 days utilizing a 10-question, abbreviated questionnaire based on the WOMAC osteoarthritis questionnaire. Supplementation with NEM® produced a significant treatment response from baseline at both 10 days and 30 days for composite pain (40.6% reduction, p p p = 0.009; 59.7% reduction, p ® is an effective and safe natural therapeutic option for the treatment of both pain and stiffness associated with osteoarthritis of the knee. Supplementation with NEM®, 500 mg taken once daily, significantly reduced both pain and stiffness rapidly (10 days) and this effect continued to improve through 30 days. There was also a meaningful reduction in the amount of analgesic consumed on a weekly basis, which further enhanced patients’ safety.