TITLE:
Human Amniotic Membrane Promotes Antimicrobial Microenvironment in a Device-Related Infection
AUTHORS:
Alice S. Ferng, Katherine M. Marsh, Tia R. Pilikian, Alana Connell, Courtney Hemphill, Samata Paidy, Ray Runyan, John Konhilas, Zain Khalpey
KEYWORDS:
Antimicrobial, Amniotic Membrane, Ventricular Assist Device
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.9 No.2,
February
29,
2016
ABSTRACT: Hospital inquired post-operative infections are a leading cause of morbidity and mortality in patients receiving left ventricular assist devices. We present the case of a patient who acquired Candida albicans and Staphylococci infections following left ventricular assist device implantation. Use of standard antibiotics caused the infection to worsen, thus an amniotic membrane patch was used as a last-resort treatment. Within 6 weeks of the amniotic membrane patch treatment, the infection resolved, the wound appeared exceptionally clean upon inspection, and granulation tissue was present. After the infection resolved, a successful latissimusdorsi tissue flap procedure was completed and the patient made a full recovery.