TITLE:
Development of Aseptic Renal Abscess in a Patient with Non-Small-Cell Lung Cancer with ALK Translocation during Crizotinib Treatment
AUTHORS:
Luciana Franco do Prado de Carvalho, Andrea Kazumi Shimada, Manuel Santos da Cruz Neto, Lucila Soares da Silva Rocha, Publio Cesar Cavalcante Viana, Esper George Kallas, Artur Katz
KEYWORDS:
Non-Small-Cell Lung Cancer, Crizotinib, Renal Abscesses
JOURNAL NAME:
Advances in Lung Cancer,
Vol.4 No.4,
February
29,
2016
ABSTRACT: Background: Crizotinib is a tyrosine kinase inhibitor of ALK, MET and
ROS1. In a safety database trial, it was suggested an association of Crizotinib
with the development of renal cyst in patients with non-small-cell lung cancer
(NSCLC). Aim: To report an uncommon side effect of Crizotinib in a patient with
NSLC. Case Presentation: We report the case of a 68-year-old woman with NSCLC
who developed bilateral progressive aseptic renal abscesses during Crizotinib
treatment. Conclusion: Further studies may be necessary to determinate the risk
of renal cyst development and the management of these complications.