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Toppari, J., Larsen, J.C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, L.J., Jegou, J., Bernard, J.T.K., Jouannet, P., Keiding, N., Leffers, H., McLachlan, J.A., Meyer, O., Muller, J., Rajpert-De, M.E., Scheike, T., Sharpe, R., Sumper, J. and Skakkebaek, N.E. (1996) Male Reproductive Health and Environmental Xenoestrogens. Environmental Health Perspectives, 104, 741-803. http://dx.doi.org/10.1289/ehp.96104s4741

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• TITLE: Evaluation of Estrogenic Receptor (ER) and Aryl Hydrocarbon Receptor (AhR) Agonists in Three Gorges Reservoir, China Using SPMD-Based Virtual Organisms

  AUTHORS: Jingxian Wang, Bernhard Henkelmann, Toine F. H. Bovee, Gerd Pfister, Liang Zhang, Karl-Werner Schramm

  KEYWORDS: ER Activity, EROD Activity, Three Gorges Reservoir, Virtual Organism, Semipermeable Membrane Device

  JOURNAL NAME: Journal of Environmental Protection, Vol.7 No.3, February 26, 2016

  ABSTRACT: The evaluation of estrogenic activities and aryl hydrocarbon receptor (AhR) agonists in water from Three Gorges Reservoir (TGR) China was conducted by in vitro bioassays combined with SPMD-based virtual organisms (VO). VOs were deployed at seven sites in the Three Gorges Reservoir (TGR), China for two periods in 2009. The estrogenic activity was assessed using a rapid yeast estrogen bioassay, based on the expression of a green fluorescent reporter protein (yEGFP). The AhR activity was detected employing rat hepatoma cell line (H4IIE). The results indicate that AhR agonists distributed widely in water of TGR and almost homogenously distributed in most area of TGR. Weak antiestrogenic activities were also found homogenously distributed in water of TGR. Further studies are needed to determine the identities of these estrogenic compounds and AhR agonists and their potential adverse effects on wild biota in TGR.