TITLE:
Sulodexide and Alzheimer’s Disease: A Preliminary Prospective Study
AUTHORS:
Joaquín Lasierra-Cirujeda, María José Aza Pascual-Salcedo, María Mercedes Aza Pascual-Salcedo
KEYWORDS:
Sulodexide, Alzheimer’s Disease, Glutathione, t-PA, PAI-1, Plasminogen, Plasmin
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.6 No.2,
February
24,
2016
ABSTRACT: The purpose of this prospective study is to determine the relative incidence of Alzheimer’s disease in patients treated for at least three years, with sulodexide (n = 46, 76.48 ± 7.02 years old) or acenocoumarol (n = 47, 78.21 ± 6.66 years old) in order to prevent primary and secondary venous thromboembolism and atherothrombotic disease. In the sulodexide group, there was an apparent prevention of cognitive and behavioural impairment (relative incidence: 2.02) compared with acenocoumarol group (relative incidence: 4.86). The favourable results in sulodexide group may be related to their pharmacodynamic actions of inhibition of PAI-1, which may interfere with the pathogenesis of Alzheimer’s disease, and to the role of glutathione and PAI-1 in the β-amyloid system in the brain.