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Cai, L., Wang, Y., Zhou, G., et al. (2006) Attenuation by metallothionein of early cardiac cell death via suppression of mitochondrial oxidative stress results in a prevention of diabetic cardiomyopathy. Journal of the American College of Cardiology, 48, 1688-1697. doi:10.1016/j.jacc.2006.07.022

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• TITLE: Uncoupling protein 2 regulates myocardial apoptosis via the diabetogenic action of streptozotocin

  AUTHORS: Xiu-Zhen Li, Ruo-Yun Tan, Xiang Lu

  KEYWORDS: Uncoupling Protein 2; Diabetes; Myocardium; Apoptosis

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.4 No.7, July 28, 2011

  ABSTRACT: Objective: Determine the role of uncoupling protein 2 (UCP2) in the myocardial apoptosis of diabetic mellitus（DM）. Methods: DM animal models were induced by streptozotocinon (STZ) on UCP2 knock-out mice (UCP2KO) and wild-type mice (WT), which were reared for 7 and 28 days after successful modeling, respectively. The expressions of relative protein for myocardial apoptosis, pro-caspase-9, were investigated using western blot. However, the terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) was used to explain apoptosis at the DNA level. Results: Image analysis showed that the expression of pro-caspase-9 protein levels increased slightly in UCP-/- + DM-7-day group comparing with DM-7-day group (P > 0.05). The expression of pro-caspase-9 protein levels increased significantly (P