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E. A. Komarova, R. V. Kondratov, K. Wang, et al., “Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice,” Oncogene, Vol. 23, 2004, pp. 3265-3271. doi:10.1038/sj.onc.1207494

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• TITLE: Predictive formulas expressing relationship among dose rate, duration of exposure and mortality probability in total body irradiation in humans

  AUTHORS: Sung Jang Chung

  KEYWORDS: Mortality Probability; Total Body Irradiation

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.4 No.7, July 28, 2011

  ABSTRACT: A clear and exact quantitative relationship between dose of radiation and mortality in humans is still not known because of lack of human data that would enable to determine LD50 for humans in total body irradiation. Analysis of human data has been primarily from radiation accidents, radiotherapy and the atomic bomb victims.The death rate equation derived from the 'probacent'-probability model of survival probability is employed in this study to construct the general formula of mortality probability as a function of dose rate and duration of exposure in total body irradiation in humans. There is a remarkable agreement between formula-predicted and published estimated LD50 and also between both mortality probabilities. The formulas of LD50 ans mortality probability in lethal radiation exposure for humans might be helpful in preventing radiation hazard and injury, and further for safety in radiotherapy.