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Wotherspoon, A.C., Ortiz-Hidalgo, C., Falzon, M.R. and Isaacson, P.G. (1991) Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet, 338, 1175-1176. doi:10.1016/0140-6736(91)92035-Z

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• TITLE: The clinical significance of CD97, NF-kB and COX-2 ingastric MALT lymphomas

  AUTHORS: Shao-Liang Han, Jun Cheng, Xiu-Ling Wu, Zeng-Rong Jia, Peng-Fei Wang, Zhan-Wei Wang

  KEYWORDS: Stomach Neoplasm; CD97; Nuclear Factor-Kb (NF-Kb); Cyclooxygenase-2 (COX-2); Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.4 No.7, July 28, 2011

  ABSTRACT: Background and Objectives: Increased expression of the CD97, nuclear factor-kB (NF-kB) and cyclooxygenase-2 (COX-2) has been found to play an important role in development of many cancers, including gastric neoplasm. However, the expression and biological behavior of CD97, NF-kB and COX-2 in gastric MALT (mucosa-associated lymphoid tissue) lymphoma has not been well investigated. Methods: The expressions of CD97, COX-2 and NF-kB in 47 cases of gastric MALT lymphoma were detected immunohistochemically, and the relevance between their expressions and the biological behavior was analyzed retrospectively. Results: 1) The expressions of CD97, NF-kB and COX-2 were 87.2%, 36.2% and 48.9%, respectively; 2) The difference of CD97 expression between depth of invasion limited in mucosa and submucosa and beyond muscularis propria was significant (100.0% vs. 71.4%, P