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Coffeen, U., Ortega-Legaspi, J.M., de Gortari, P., Simón-Arceo, K., Jaimes, O., Amaya, M.I. and Pellicer, F. (2010) Inflammatory Nociception Diminishes Dopamine Release and Increases Dopamine D2 Receptor mRNA in the Rat’s Insular Cortex. Molecular Pain, 6, 75. http://dx.doi.org/10.1186/1744-8069-6-75

has been cited by the following article:

• TITLE: Extracellular Levels of 5HT and 5HIAA Increase after an Inflammatory Process in the Rat’s Insular Cortex

  AUTHORS: Ulises Coffeen, Ana Canseco-Alba, Karina Simón-Arceo, Francisco Mercado, Angélica Almanza, Orlando Jaimes, Francisco Pellicer

  KEYWORDS: Pain, Inflammation, Insular Cortex, 5HT, 5HIAA

  JOURNAL NAME: World Journal of Neuroscience, Vol.6 No.1, February 14, 2016

  ABSTRACT: Serotonin (5HT) in the central nervous system has been associated with pain processing and modulation. The insular cortex (IC) plays an important role in the development and perception of the inflammatory and chronic pain. The role of the serotoninergic system in IC has not been completely studied. We used micro-dialysis in freely moving rats to determine the extracellular release of 5HT and its main metabolite (5HIAA) in the IC during an inflammatory process. Results showed an increase of extracellular levels of 5HT and 5HIAA in the IC during carrageenan-induced inflammation and this augmentation correlates with a decrease of behavioral mechanonociceptive response. Furthermore, the exogenous administration of 5HT and 5HIAA in the IC increases the nociceptive response. Our current data imply that the serotoninergic system in the IC participates in the long-term pain process.