TITLE:
Carbohydrate Intake Is Correlated with the Glycated Albumin to Glycated Hemoglobin Ratio in Drug-Naive Patients with Type 2 Diabetes
AUTHORS:
Satoru Sumitani, Yoshihiko Utsu, Shuhei Nishina, Kenta Okuro, Atsushi Kogetsu, Seigo Ishii, Akiko Deguchi, Bunzo Sato, Isao Tachibana, Soji Kasayama, Masafumi Koga
KEYWORDS:
Glycated Albumin, HbA1c, Type 2 Diabetes Mellitus, Carbohydrate, Postprandial Hyperglycemia
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.6 No.1,
February
2,
2016
ABSTRACT: Background: The glycated albumin (GA) to HbA1c ratio (GA/HbA1c ratio) has been
reported to reflect postprandial hyperglycemia. Carbohydrate is the primary
dietary macronutrient that causes postprandial hyperglycemia. Thus, we
investigated whether carbohydrate intake was associated with the GA/HbA1c ratio
in patients with type 2 diabetes. Methods:
Daily energy intake and carbohydrate intake were estimated in twenty-two patients
with type 2 diabetes who received no pharmacological therapy (18 men and 4
women, age 53 ± 11 years old). The energy index and the carbohydrate index were
defined as the ratio of daily energy intake to body weight and daily carbohydrate
intake to body weight, respectively. Results:
The energy index was significantly correlated with the GA/HbA1c ratio (r = 0.451,
p = 0.035), but not with fasting plasma glucose (FPG), HbA1c and GA. The carbohydrate
index was significantly correlated with GA (r = 0.461, p = 0.031) and the
GA/HbA1c ratio (r = 0.554, p = 0.007), but not with FPG and HbA1c. Multivariate
analysis revealed that the carbohydrate index was independently associated with
the GA/HbA1c ratio (β = 0.397, p = 0.046). Conclusions: The carbohydrate index was
significantly correlated with GA and the GA/HbA1c ratio in the patients with
type 2 diabetes. These results suggest that carbohydrate intake may be
associated with the GA/HbA1c ratio through postprandial hyperglycemia.