TITLE:
Correlation of Equol (7-Hydroxy-3-(4-Hydroxyphenyl)Chroman) in Woman Urine with the Symptoms of Menopause
AUTHORS:
Rima Yulia Effriyanti, Tita Husnitawati Madjid, Hanom Husni Syam
KEYWORDS:
Equol, Menopause Symptoms, Menopause Rating Scale
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.4 No.1,
January
28,
2016
ABSTRACT: Objective: In order to identify the correlation between equol excreted through human urine and the symptom of menopause. Methods: The method used is cross sectional study examined to 99 postmenopausal women fulfilling the inclusion criteria from February 2014 to July 2014. This research was taken in the Endocrinology Clinic, Department of Obstetrics and Gynecology, Hasan Sadikin Hospital and Unpad’s Pharmacokinetic Laboratory. All objects were interviewed using menopause rating scale (MRS) questionnaire. Their urine samples were analyzed using high performance liquid chromatography (HPLC). Then the results of questionnaire and HPLC test were evaluated. Results: The result is 97 objects (98%) detected having menopausal symptoms, produced equol. There is significant correlation between the level of equol in post-menopausal women that showed correlation (－0.71) which mean the higher the equol level, the lower the MRS score (p