TITLE:
Non Selective Inhibition of COX Activity Reversed Inflammation and Reactive Oxygen Radicals Mediated Prostate Cancer Risk and Decreased Disease Progression in Preclinical Model
AUTHORS:
Maxwell Omabe, Kenneth Nwobini Omabe, Clement Ademola Famurewa, Alberta Egwu Okorocha, Grace Maxwell Omabe
KEYWORDS:
Inflammation, Prostate Cancer, Reactive Oxygen Species
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.7 No.1,
January
28,
2016
ABSTRACT: Prostate cancer (PCa) represents the most frequent urologic diagnosis in
elderly males. We have previously shown that exposure of prostate to
lipopolysaccharide (LPS) promotes cancer risk. We investigated the effect of
non-selective cyclooxygenase (COX) inhibition on prostate inflammation-mediated
cancer risk in vivo. The prostates of
male rats were inoculated with E. coli as sources of inflammatory molecules (LPS) and were treated with COX inhibitor,
aspirin 2 mg/Kg orally for 14 days or PBS. Oxidative stress was induced with
two 2 mls of hydrogen peroxide orally twice daily or PBS for 14 days; they were
either treated with COX inhibitor or PBS for another 14 days. Blood was
collected and analyzed for acid phosphatase and PSA. Data showed presences of
LPS in the prostate of the rats resulted in gradual increase in PSA when
compared to control (P P 2O2 had
2.5 fold increase in acid phosphatase (ACP) compared control (P P ity in rats.