TITLE:
Solvent Effects on the UV Absorption Spectrum of Carmofur
AUTHORS:
Peipei Zhang, Shuyu Liu
KEYWORDS:
Solvent-Induced, Carmofur, Conformation, UV Spectra
JOURNAL NAME:
Detection,
Vol.4 No.1,
January
22,
2016
ABSTRACT: In this article, we reported that carmofur could be induced by some solvent to produce conformational
alteration. Ultraviolet (UV) spectra were used to study the conformation alteration of carmofur.
Upon the addition of acid in the some solvent, UV spectroscopy of carmofur could change
gradually. When base was added to this system, UV spectroscopy of carmofur could return to the
original state, and the change process was reversible. The variable temperature 1H and 13C-NMR
spectrum were used to testify that temperature did not have any effect on the conformation alteration
of carmofur in Acetonitrile: Trifluoroacetic-acid (9:1). These two conformers of carmofur
were structurally stable in Acetonitrile: Trifluoroacetic-acid (9:1).