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Yoshida, M., Kubota, D., Yonezawa, S., Nakamura, H., Azechi, H. and Terakado, N. (1971) Transfer of Dietary Spiramycin into the Eggs and Its Residue in the Liver of Laying Hen. Japan Poultry Science, 8, 103-110.
https://www.jstage.jst.go.jp/article/jpsa1964/8/2/8_2_103/_pdf
http://dx.doi.org/10.2141/jpsa.8.103

has been cited by the following article:

• TITLE: Pharmacokinetics and Tissue Residues of Tylosin in Broiler Chickens

  AUTHORS: Ahmed M. Soliman, Mahmoud Sedeik

  KEYWORDS: Pharmacokinetics, Tylosin, Broiler Chickens, Bioavailability, Tissue Residue

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.7 No.1, January 18, 2016

  ABSTRACT: The pharmacokinetics and tissue residue of tylosin in broiler chickens were studied after I.V. and oral administrations in a dose of 50 mg tylosin/kg.b.wt. Tylosin was obeyed a two-compartment open model following I.V. administration at a dose of 50 mg/kg.b.wt. The disposition kinetics of tylosin following I.V. administration revealed that tylosin was highly distributed with Vd(area) of 6 L/kg and eliminated with half-life (t1/2β) equal to 7.29 hours. The disposition kinetics of tylosin following oral administration revealed that the maximum blood concentration (Cmax) was 3.40 μg/ml attained at (tmax) of 1.08 hour. Tylosin was eliminated with half-life (t1/2β) equal to 5.78 hours. The mean systemic bioavailability of tylosin after oral administration was 90.29%. Following repeated oral administration of 50 mg tylosin base/kg.b.wt once daily for 5 consecutive days, the blood (μg/ml) and tissue (μg/g) residues of tylosin showed that liver, kidney and lung contained the highest tylosin residues and completely disappeared from those tissues at 6 days after the last oral dose. Chickens should not be slaughtered for human consumption within the treatment and 6 days after the last oral administrations of tylosin.