TITLE:
Case Reports: Treatment-Resistant Schizophrenia with Severe Type 2 Diabetes Mellitus Treated with Clozapine
AUTHORS:
Junji Gon, Shinji Sakamoto, Manabu Takaki
KEYWORDS:
Clozapine, Treatment-Resistant Schizophrenia, Type 2 Diabetes Mellitus, Brief Assessment of Cognition in Schizophrenia Japanese Version
JOURNAL NAME:
Open Journal of Psychiatry,
Vol.6 No.1,
January
11,
2016
ABSTRACT: Objective: Clozapine is
regarded as the most effective drug for treatment of schizophrenia but has
complex adverse effects associated with hyperglycemia and diabetes mellitus.
Method: We report that clozapine was very effective to treat positive,
negative, and cognitive symptoms and well tolerated to a treatment-resistant
schizophrenia patient with severe type 2 diabetes mellitus (DM) under cautious blood-sugar
monitoring. Results: Clozapine itself and discontinuation of other psychotropic
and anticholinergic agents after switching may improve cognitive function and
adherence to the treatment regimens for schizophrenia and DM. Conclusion:
Clozapine can be administered to treatment-resistant schizophrenia patients
even with severe DM with caution.