TITLE:
Hydrophilic Silica/Copolymer Nanoparticles and Protein-Resistance Coatings
AUTHORS:
Hongpu Huang, Ling He
KEYWORDS:
Silica/Copolymer, Hydrophilic Nanoparticles, Tem-Responsive, Protein-Resistance, Coatings
JOURNAL NAME:
Journal of Materials Science and Chemical Engineering,
Vol.4 No.1,
January
11,
2016
ABSTRACT: Hydrophilic silica/copolymer nanoparticles
of SiO2-g-P(PEGMA)-b-P(PEG) are prepared by silica surface-initiating atom
transfer radical polymerization (SI-ATRP) of poly (ethylene glycol) methyl
ether methacrylate (PEGMA) and poly(ethylene glycol) methacrylate (PEG), by
using Three molar ratios of SiO2-Br/PEGMA/PEG as 1/42.46/19.44, 1/42.46/38.88
and 1/42.46/77.76. Their temperature sensitive behaviour, pH response and
surface properties as protein-resistance coatings are characterized. 220 nm
core-shell nanoparticles as P(PEGMA)-b-P(PEG) shell grafted on SiO2 core are
formed in water solution, which gained LCST at 60。C - 77。C and good dispersion
in water when pH > 5.0. The water-casted films by SiO2-g-P(PEGMA)-b-P(PEG)
obtain a little rough surface (Ra = 26.8 - 29.7 nm). While, the introduction
of P(PEG) segments could slight increase the protein-repelling adsorption of
SiO2-g-P(PEGMA)-b-P(PEG) films (△f = ?6.96 Hz ~ ?7.25 Hz) compared with SiO2-g-P(PEGMA) films (△f = ?9.5 Hz). Therefore,
SiO2-g-P(PEGMA)-b-P(PEG) could be used as protein-resistance coatings.