TITLE:
Morphofunctional Characteristics of Pulmonary Surfactant System and Its Effect on Immune Cells in Influenza A (H1N1) Pathogenesis
AUTHORS:
A. V. Kovner, O. V. Potapova, V. A. Shkurupy, A. M. Shestopalov
KEYWORDS:
Influenza A (H1N1) Virus, Pulmonary Surfactant system, SP-A, M1/M2 Macrophages, Antiviral Defense
JOURNAL NAME:
Open Journal of Pathology,
Vol.6 No.1,
January
6,
2016
ABSTRACT: There is an annual increase of
influenza-related SARI cases in winter months. Despite the high relevance of
this problem, influenza pathogenesis and the role of surfactant system and its
SP-A (surfactant protein A) enzyme in antiviral defense remain poorly
understood. SP-A activates macrophage M1 polarization and triggers an
antiviral response due to the activation of T-cells and dendritic cells.
Therefore, surfactant system is an important element of infection protection
and a promising therapeutic target.