TITLE:
Could Low Hdl-Cholesterol Levels Be an Unvalued Predictor of Cancer Risk?: A Retrospective Case Study
AUTHORS:
Juan Antonio Vílchez, Natalia Sancho-Rodríguez, Ana Martínez-Ruiz, Enrique Martínez-Sánchez, Francisco Ruiz-Espejo, Isabel Tovar-Zapata, Jose Antonio Noguera-Velasco
KEYWORDS:
High-Density Lipoprotein Cholesterol (HDL), Cancer Risk, Lipid Profile, Carcinoembryonic Antigen (CEA)
JOURNAL NAME:
International Journal of Clinical Medicine,
Vol.6 No.12,
December
31,
2015
ABSTRACT: Background: The relationship between serum lipid profile levels and cancer risk remained uncertain. Recently, it had been reported a significant inverse association between high-density lipoprotein cholesterol (HDL) and the risk of incident cancer that was independent of low-density lipoprotein cholesterol (LDL), age or sex. Objective: The aim of our study was to evaluate the behavior of HDL in cancer patients and in healthy population. Methods: We created a retrospectively search strategy in the laboratory information system (LIS). We filtered and searched those patients with CEA within 5 - 20 ng/ml and any value of HDL and corroborated the presence of cancer (Group 1 (G1)) or not (Group 2 (G2)). Moreover, we searched a control group (patients in outpatient oncology clinic) to observe the values of HDL. Comparisons and statistical logistic regression models were applied to link the levels of this biomarkers and cancer risk. Results: We examined 852 valid patients, median age 62 (50 - 73) years. Within the search strategy group, G2 showed highest levels of HDL (54 (43 - 67) mg/dl) and lowest CEA levels (6.7 (5.7 - 8.4) ng/ml) comparing with G1: HDL (47 (37 - 60) mg/dl) and the CEA (7.9 (6.2 - 10.9) ng/ml); p p r2: 0.092; p p = 0.001)] and CEA [OR: 1.115 (1.060 - 1.174), (p