TITLE:
Nanoscale Stiffness Distribution in Bone Metastasis
AUTHORS:
Ludovic Richert, Laetitia Keller, Quentin Wagner, Fabien Bornert, Catherine Gros, Sophie Bahi, François Clauss, William Bacon, Philippe Clézardin, Nadia Benkirane-Jessel, Florence Fioretti
KEYWORDS:
Bone Metastasis, Stiffness, Risedronate
JOURNAL NAME:
World Journal of Nano Science and Engineering,
Vol.5 No.4,
December
31,
2015
ABSTRACT: Nanomechanical heterogeneity is expected to have an effect on elasticity, injury and bone remodelling. In normal bone, we have two types of cells (osteoclasts and osteoblasts) working together to maintain existing bone. Bone cancers can produce factors that make the osteoclasts work harder. This means that more bone is destroyed than rebuilt, and leads to weakening of the affected bone. We report here the first demonstration of the nanoscale stiffness distribution in bone metastases before and after treatment of animals with the bisphosphonate Risedronate, a drug which is currently used for the treatment of bone metastases in patients with advanced cancers. The strategy used here is applicable to a wide class of biological tissues and may serve as a new reflection for biologically inspired scaffolds technologies.