TITLE:
NQO1 Pro187Ser Polymorphism Confers to the Susceptibility of Prostate Cancer
AUTHORS:
Xiaofei Zhang, Wei Jiao, Wenhua Zhang
KEYWORDS:
NQO1, Polymorphism, Prostate, Cancer, Meta-Analysis
JOURNAL NAME:
Open Journal of Urology,
Vol.5 No.12,
December
28,
2015
ABSTRACT: Increasing epidemiological studies were
recently performed to assess the relationship of NAD(P)H: quinine
oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of prostate cancer
(PCa) to yield inconsistent results. In this study, we aimed to generate
large-scale evidence on whether NQO1 Pro187Ser polymorphism conferred to the
susceptibility of PCa. The database of PubMed was comprehensively reviewed until
September 12th, 2013, without any linguistic limitation. Meta-analysis was
complied in the codominant, dominant, recessive and allele models by either
fixed or random effect models. Odds ratios (OR) and 95% confidence intervals
(95%CI) were calculated to evaluate the strength of the association between
the two. Finally, six eligible studies with 717 cases and 1764 controls were
included. In overall analyses, significant associations were found in the
dominant (OR = 1.26, 95%CI = 1.04 - 1.52, P = 0.02), allele (OR = 1.20, 95%CI =
1.03 - 1.40, P = 0.02) and the heterozygous codominant (OR = 1.24, 95%CI = 1.02
- 1.52, P = 0.03) models. Also, significant results were found in the
stratified analyses by Hardy-Weinberg equilibrium (HWE). Still, subgroup analysis
showed an increased risk of PCa in Asian rather than Caucasian population.
Besides, NQO Pro187Ser polymorphism correlated with a heightened risk of PCa in
the hospital-based studies. Our study indicated that NQO1 functional Pro187Ser
polymorphism could be a potentially genetic biomarker for the risk of PCa,
especially in Asian population.