Article citationsMore>>

H. Hussain, B. H. Tan, G. L. Seah, Y. Liu, C. B. He and T. P. Davis, “Micelle Formation and Gelation of (PEG-P(MA-POSS)) Amphiphilic Block Copolymers via Associative Hydrophobic Effects,” Langmuir, Vol. 26, No. 14, 2010, pp. 11763–11773.; B. H. Tan, H. Hussain and C. B. He, “Tailoring Micelle Formation and Gelation in (PEG-P(MA-POSS)) Amphiphilic Hybrid Block Copolymers,” Macromolecules, Vol. 44, 2011, pp. 622-631.

has been cited by the following article:

• TITLE: Self-Assembled Core-Shell Poly(ethylene glycol)-POSS Nanocarriers for Drug Delivery

  AUTHORS: Kyu-Oh Kim, Byoung-Suhk Kim, Ick-Soo Kim

  KEYWORDS: Self-assembly, Amphiphilic, Nanoparticles, POSS, Insulin, Oral delivery

  JOURNAL NAME: Journal of Biomaterials and Nanobiotechnology, Vol.2 No.3, May 6, 2011

  ABSTRACT: In this work, novel nanostructured core-shell poly(ethylene glycol) (PEG)-polyhedral oligosilsesquioxane (POSS) nanoparticles were used to encapsulate insulin as new drug delivery carriers. The morphologies, particle size and ζ potential of the pure nanostructured core-shell PEG-POSS and the corresponding insulin-loaded PEG-POSS nanoparticles were investigated by transmission electron microscopy (TEM) and laser diffraction particle sizer. TEM analysis demonstrated that pure and insulin-loaded self-assembled PEG-POSS nanoparticles were of spherical shape with core-shell nanostructure, and were well-dispersed and uniform in size distribution. Insulin release test showed that insulin was well-protected inside PEG-POSS nanoparticles at gastric pH for 2hrs, and was released at intestinal pH (pH 6-7) where the absorption and activation of the drug are necessary. We therefore believe that such nanostructured PEG-POSS nanoparticles could be useful as a potential carrier for insulin drug delivery systems.